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We in contrast benefits with the RAMQ study acquired Along with the comprehensive list of 18 IPD meta-analysis confounders with just the six typical IPD meta-analysis confounders.
We also retrieved systematic assessments of non-randomised experiments of cardiovascular adverse gatherings connected with NSAIDs and manually searched their bibliography. To increase sensitivity for the myocardial infarction final result, we bundled broader conditions for cardiac morbidity. After an Preliminary lookup, we setup weekly updates from June 2010 to November 2013.
For exposures and confounders which have been absolutely missing in the IPD meta-analysis typical composition, we considered an alternate assumption that these had been missing at random and will be obtained by multiple imputation.4748 We concluded this was implausible while in the context of observational scientific studies sourced from healthcare databases (see Net appendix 3).
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This aspect might explain why the myocardial infarction possibility of NSAIDs was uncovered 1st through rofecoxib trials. Our study implies a more compact possibility of myocardial infarction exists with all other NSAIDs.
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